If you’re looking to wow your friends and family with a dish that brings together bold flavors, juicy tenderness, and a true hit of smoke, the Jack’d Up Smoked Meatloaf is your ticket to comfort food perfection. This isn’t your ordinary weeknight meatloaf—think savory ground beef and pork melded together with gooey pepper jack cheese, kissed by the warmth of hickory smoke, and made unforgettable with a whiskey-kissed barbecue glaze. Whether you’re a seasoned smoker or this is your first foray into backyard barbecue, Jack’d Up Smoked Meatloaf will become the dish everyone requests by name!

Ingredients You’ll Need
Gathering the ingredients for Jack’d Up Smoked Meatloaf is a breeze—they’re easy to find, yet each one plays a pivotal role in achieving that perfect blend of flavor, texture, and rich color. Here’s what each handpicked element brings to the party:
- Ground beef (80/20): The magic ratio for juicy, flavorful meatloaf with plenty of moisture.
- Ground pork: Adds tenderness and a subtle sweetness that complements the beef.
- Breadcrumbs: The binder that keeps your loaf together while soaking up all those savory juices.
- Whole milk: Helps soften the breadcrumbs for a tender, never-dry bite.
- Large eggs: Essential for binding everything together, they create a cohesive texture.
- Small onion, finely chopped: Gives a gentle bite and bursts of sweetness throughout the loaf.
- Garlic, minced: Brings aromatic depth and a punch of flavor to every slice.
- Ketchup: Adds tanginess and that classic meatloaf undertone.
- Worcestershire sauce: Infuses rich umami that amplifies the smoky notes.
- Yellow mustard: A dash of bright acidity keeps the flavors vibrant and balanced.
- Salt: Pulls out the natural flavors of every ingredient—it’s the subtle backbone.
- Black pepper: Provides a gentle kick to balance the richness.
- Smoked paprika: Doubles down on smoky complexity before the loaf even hits the smoker.
- Cayenne pepper: Just enough to tantalize your taste buds without overwhelming the senses.
- Pepper jack cheese, shredded: Melts into pockets of creamy, spicy goodness inside each slice.
- Barbecue sauce (for glazing): Forms that irresistible, sticky-sweet, caramelized top layer.
- Jack Daniel’s whiskey (optional): A splash in the glaze or mix elevates the flavor with a hint of smoke and caramel—substitute beef broth or skip if you prefer.
How to Make Jack’d Up Smoked Meatloaf
Step 1: Soak the Breadcrumbs
Start by making a panade to ensure your Jack’d Up Smoked Meatloaf is unbelievably moist. Mix the breadcrumbs with whole milk in a large bowl, then let them soak for a few minutes while you prep your other ingredients. This simple step is the secret to a meltingly tender texture.
Step 2: Combine the Meats and Flavorings
Add the ground beef, ground pork, eggs, finely chopped onion, minced garlic, ketchup, Worcestershire sauce, mustard, salt, black pepper, smoked paprika, and cayenne pepper to the breadcrumb mixture. Sprinkle in the shredded pepper jack cheese, and if you’re feeling adventurous, pour in the Jack Daniel’s whiskey. Use your hands to gently mix everything together until just combined—overmixing can make the loaf dense, so think gentle folds.
Step 3: Shape Your Loaf
Place your meat mixture on a piece of foil or a grill-safe baking tray. Shape it into a rustic loaf, making sure it’s even for uniform cooking. Avoid packing it too tightly, as a loosely shaped loaf will allow smoke and heat to move through for more flavor and better texture.
Step 4: Smoke the Meatloaf
Transfer your shaped loaf into a preheated smoker set at 250°F, loaded with hickory or mesquite wood for maximum flavor. Smoke the Jack’d Up Smoked Meatloaf for 2.5 to 3 hours, or until the internal temperature reaches 160°F. The aroma at this step is heavenly—it’s hard not to peek!
Step 5: Glaze and Finish on the Smoker
About 30 minutes before you plan to pull your meatloaf from the smoker, brush the top generously with barbecue sauce. This coating will set into a glossy, sticky glaze with a marvelous blend of sweet, tangy, and smoky. Let it caramelize as the loaf finishes smoking to perfection.
Step 6: Rest and Slice
Patience pays off! Remove your Jack’d Up Smoked Meatloaf from the smoker and let it rest, lightly tented with foil, for 10 to 15 minutes. This helps the juices redistribute, making every slice juicy and full of flavor. Once rested, slice thickly and serve to hungry friends and family.
How to Serve Jack’d Up Smoked Meatloaf

Garnishes
Add flair to every plate by topping your hot slices with crispy fried onions or a sprinkle of fresh chopped parsley for color and crunch. These finishing touches make your Jack’d Up Smoked Meatloaf as stunning to look at as it is delicious to eat.
Side Dishes
This meatloaf’s hearty, smoky flavor pairs beautifully with creamy mashed potatoes, roasted seasonal vegetables, or classic mac and cheese. For something lighter, a crisp green salad with tangy vinaigrette helps balance the richness, making your meal feel restaurant-worthy.
Creative Ways to Present
Transform leftovers into drool-worthy sandwiches with a slather of extra barbecue sauce and crunchy pickles. For a playful twist at your next gathering, cut the Jack’d Up Smoked Meatloaf into cubes, skewer them, and serve with dipping sauce for a crowd-pleasing appetizer.
Make Ahead and Storage
Storing Leftovers
Any remaining Jack’d Up Smoked Meatloaf can be wrapped tightly and placed in the refrigerator for up to three days. The flavors deepen as it rests, making leftovers especially tasty the next day, perfect for quick lunches or late-night snacks.
Freezing
This meatloaf freezes beautifully! Slice it into portions, wrap each securely in plastic or foil, and store in an airtight container or freezer bag. Jack’d Up Smoked Meatloaf will stay at its best for up to two months in the freezer—just thaw when cravings strike.
Reheating
For best results, reheat slices gently in a 300°F oven, covered with foil to lock in the moisture. You can also microwave leftovers, but be sure to use a lower power setting and add a splash of broth or water to keep it from drying out.
FAQs
Can I make Jack’d Up Smoked Meatloaf without a smoker?
Absolutely! If you don’t have a smoker, bake the meatloaf in your oven at 350°F. For smoky flavor, add a touch of liquid smoke to the mix or use smoked paprika generously in the seasoning blend.
What type Main Course
Hickory and mesquite bring the boldest flavors to Jack’d Up Smoked Meatloaf, but apple or cherry wood chips add a milder, slightly sweet smoke. Feel free to experiment and see which suits your taste best!
Is there a gluten-free option for this recipe?
Yes! Simply swap your favorite gluten-free breadcrumbs for the traditional kind. Everything else in the recipe is naturally gluten-free, so everyone can enjoy a slice.
Can I substitute the whiskey in this recipe?
Certainly. If you prefer not to use alcohol, just swap in beef broth for depth, or you can leave it out altogether. The result will still be crowd-pleasing and loaded with flavor.
How do I keep the meatloaf from falling apart?
Be sure to use the breadcrumbs, milk, and eggs as instructed—these ingredients help bind everything together. Mixing gently (not overworking) is also key to maintaining the perfect sliceable texture.
Final Thoughts
This Jack’d Up Smoked Meatloaf is a labor of love that rewards you with every smoky, cheesy, perfectly glazed bite. Whether it’s your first time or your favorite Saturday tradition, give it a try—you might just turn a classic comfort food into a new signature dish!
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Jack’d Up Smoked Meatloaf Recipe
- Prep Time: 20 minutes
- Cook Time: 3 hours
- Total Time: 3 hours 20 minutes
- Yield: 6–8 servings
- Category: Main Course
- Method: Smoking
- Cuisine: American
- Diet: Non-Vegetarian
Description
This Jack’d Up Smoked Meatloaf recipe takes the classic comfort food to a whole new level with a blend of beef and pork, savory seasonings, and a spicy, cheesy kick. Infused with smoky flavor from the grill and glazed with a sweet barbecue sauce, it’s a must-try for meatloaf lovers.
Ingredients
Meatloaf:
- 2 pounds ground beef (80/20)
- 1/2 pound ground pork
- 1 cup breadcrumbs
- 1/2 cup whole milk
- 2 large eggs
- 1 small onion, finely chopped
- 3 cloves garlic, minced
- 1/2 cup ketchup
- 2 tablespoons Worcestershire sauce
- 1 tablespoon yellow mustard
- 1 teaspoon salt
- 1/2 teaspoon black pepper
- 1/2 teaspoon smoked paprika
- 1/4 teaspoon cayenne pepper
- 1/2 cup shredded pepper jack cheese
- 1/4 cup barbecue sauce (for glazing)
- Optional: 1/4 cup Jack Daniel’s whiskey (for added flavor in glaze or mix)
Instructions
- Preheat the Smoker: Preheat your smoker to 250°F using hickory or mesquite wood for a bold flavor.
- Prepare the Meat Mixture: In a large bowl, mix breadcrumbs and milk to form a panade. Add beef, pork, eggs, onion, garlic, ketchup, Worcestershire sauce, mustard, salt, pepper, smoked paprika, cayenne, and pepper jack cheese. Gently mix by hand until just combined.
- Shape and Smoke: Shape the meat mixture into a loaf on foil or a baking tray. Smoke for 2.5 to 3 hours until the internal temperature reaches 160°F.
- Glaze and Rest: During the last 30 minutes, brush the top with barbecue sauce. Let the meatloaf rest for 10–15 minutes before slicing and serving.
Notes
- You can substitute the whiskey with beef broth or omit it entirely.
- For extra texture, top the meatloaf with fried onions after glazing.
- Leftovers make excellent sandwiches the next day.
Nutrition
- Serving Size: 1 slice
- Calories: 430
- Sugar: 7g
- Sodium: 520mg
- Fat: 28g
- Saturated Fat: 11g
- Unsaturated Fat: 14g
- Trans Fat: 0.5g
- Carbohydrates: 14g
- Fiber: 1g
- Protein: 30g
- Cholesterol: 135mg